PGE(2) Desensitizes β-Agonist Effect on Human Lung Fibroblast-Mediated Collagen Gel Contraction through Upregulating PDE4

In the current study, we investigated the effect of a long-acting β-agonist (salmeterol) and a phosphodiesterase 4 (PDE4) inhibitor (cilomilast) on human lung fibroblast-mediated collagen gel contraction. Higher concentrations of salmeterol (10(−7) and 10(−6) M) inhibited fibroblast-mediated collage...

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Detalhes bibliográficos
Main Authors: Fang, Qiuhong, Ma, Yingmin, Wang, Jing, Michalski, Joel, Rennard, Stephen I., Liu, Xiangde
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817676/
https://ncbi.nlm.nih.gov/pubmed/24227907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/145197
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