IL-17 Induced Autophagy Regulates Mitochondrial Dysfunction and Fibrosis in Severe Asthmatic Bronchial Fibroblasts

The accumulation of fibroblasts, their synthesis of extracellular matrix (ECM) proteins and their innate resistance to apoptosis are characteristics of subepithelial fibrosis observed in severe asthma. Interleukin-17 (IL-17) is an important regulator of airway remodeling in asthma. However, the cont...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Ramakrishnan, Rakhee K., Bajbouj, Khuloud, Al Heialy, Saba, Mahboub, Bassam, Ansari, Abdul Wahid, Hachim, Ibrahim Y., Rawat, Surendra, Salameh, Laila, Hachim, Mahmood Y., Olivenstein, Ronald, Halwani, Rabih, Hamoudi, Rifat, Hamid, Qutayba
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326148/
https://ncbi.nlm.nih.gov/pubmed/32670268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01002
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