IL-17 Induced Autophagy Regulates Mitochondrial Dysfunction and Fibrosis in Severe Asthmatic Bronchial Fibroblasts

The accumulation of fibroblasts, their synthesis of extracellular matrix (ECM) proteins and their innate resistance to apoptosis are characteristics of subepithelial fibrosis observed in severe asthma. Interleukin-17 (IL-17) is an important regulator of airway remodeling in asthma. However, the cont...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Ramakrishnan, Rakhee K., Bajbouj, Khuloud, Al Heialy, Saba, Mahboub, Bassam, Ansari, Abdul Wahid, Hachim, Ibrahim Y., Rawat, Surendra, Salameh, Laila, Hachim, Mahmood Y., Olivenstein, Ronald, Halwani, Rabih, Hamoudi, Rifat, Hamid, Qutayba
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326148/
https://ncbi.nlm.nih.gov/pubmed/32670268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01002
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