Mechanistic Population Pharmacokinetic Model of Oseltamivir and Oseltamivir Carboxylate Accounting for Physiological Changes to Predict Exposures in Neonates and Infants

A mechanistic population‐pharmacokinetic model was developed to predict oseltamivir exposures in neonates and infants accounting for physiological changes during the first 2 years of life. The model included data from 13 studies, comprising 436 subjects with normal renal function (317 pediatric subj...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Gibiansky, Leonid, Ravva, Patanjali, Parrott, Neil J., Bhardwaj, Rajinder, Zwanziger, Elke, Grimsey, Paul, Clinch, Barry, Sturm, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325316/
https://ncbi.nlm.nih.gov/pubmed/31957010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1791
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