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Nonclinical Pharmacokinetics of Oseltamivir and Oseltamivir Carboxylate in the Central Nervous System

Oseltamivir, a potent and selective inhibitor of influenza A and B virus neuraminidases, is a prodrug that is systemically converted into the active metabolite oseltamivir carboxylate. In light of reported neuropsychiatric events in influenza patients, including some taking oseltamivir, and as part...

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Bibliographic Details
Main Authors: Hoffmann, Gerhard, Funk, Christoph, Fowler, Stephen, Otteneder, Michael B., Breidenbach, Alexander, Rayner, Craig R., Chu, Tom, Prinssen, Eric P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772352/
https://ncbi.nlm.nih.gov/pubmed/19721074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01541-08
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