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A chemical proteomic probe for the mitochondrial pyruvate carrier complex
Target engagement assays are crucial for establishing the mechanism-of-action of small molecules in living systems. Integral membrane transporters, due to their specialized biophysical properties and activity assays, can present a challenging protein class for assessing cellular engagement by small...
Guardat en:
| Publicat a: | Angew Chem Int Ed Engl |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7323913/ https://ncbi.nlm.nih.gov/pubmed/31863675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201914391 |
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