Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients

Trauma-induced coagulopathy (TIC) is a complex, multifactorial failure of hemostasis that occurs in 25% of severely injured patients and results in a fourfold higher mortality. However, the role of platelets in this state remains poorly understood. We set out to identify molecular changes that may u...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Vulliamy, Paul, Montague, Samantha J., Gillespie, Scarlett, Chan, Melissa V., Coupland, Lucy A., Andrews, Robert K., Warner, Timothy D., Gardiner, Elizabeth E., Brohi, Karim, Armstrong, Paul C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322946/
https://ncbi.nlm.nih.gov/pubmed/32556282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001776
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