Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells

Nucleotide excision repair (NER) removes helix-destabilizing adducts including ultraviolet (UV) lesions, cyclobutane pyrimidine dimers (CPDs), and pyrimidine (6–4) pyrimidone photoproducts (6–4PPs). In comparison with CPDs, 6–4PPs have greater cytotoxicity and more strongly destabilizing properties...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Saha, Liton Kumar, Wakasugi, Mitsuo, Akter, Salma, Prasad, Rajendra, Wilson, Samuel H., Shimizu, Naoto, Sasanuma, Hiroyuki, Huang, Shar-yin Naomi, Agama, Keli, Pommier, Yves, Matsunaga, Tsukasa, Hirota, Kouji, Iwai, Shigenori, Nakazawa, Yuka, Ogi, Tomoo, Takeda, Shunichi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321995/
https://ncbi.nlm.nih.gov/pubmed/32513688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920165117
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