Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations

Xeroderma pigmentosum group G (XPG) protein is both a functional partner in multiple DNA damage responses (DDR) and a pathway coordinator and structure-specific endonuclease in nucleotide excision repair (NER). Different mutations in the XPG gene ERCC5 lead to either of two distinct human diseases:...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Tsutakawa, Susan E., Sarker, Altaf H., Ng, Clifford, Arvai, Andrew S., Shin, David S., Shih, Brian, Jiang, Shuai, Thwin, Aye C., Tsai, Miaw-Sheue, Willcox, Alexandra, Her, Mai Zong, Trego, Kelly S., Raetz, Alan G., Rosenberg, Daniel, Bacolla, Albino, Hammel, Michal, Griffith, Jack D., Cooper, Priscilla K., Tainer, John A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321962/
https://ncbi.nlm.nih.gov/pubmed/32522879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921311117
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