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XPG-related nucleases are hierarchically recruited for double-stranded rDNA break resection

dsDNA breaks (DSBs) are resected in a 5′→3′ direction, generating single-stranded DNA (ssDNA). This promotes DNA repair by homologous recombination and also assembly of signaling complexes that activate the DNA damage checkpoint effector kinase Chk1. In fission yeast (Schizosaccharomyces pombe), gen...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Barnum, Kevin J., Nguyen, Y. Tram, O'Connell, Matthew J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514642/
https://ncbi.nlm.nih.gov/pubmed/30885940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005415
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