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XPG-related nucleases are hierarchically recruited for double-stranded rDNA break resection
dsDNA breaks (DSBs) are resected in a 5′→3′ direction, generating single-stranded DNA (ssDNA). This promotes DNA repair by homologous recombination and also assembly of signaling complexes that activate the DNA damage checkpoint effector kinase Chk1. In fission yeast (Schizosaccharomyces pombe), gen...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6514642/ https://ncbi.nlm.nih.gov/pubmed/30885940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005415 |
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