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XPG-related nucleases are hierarchically recruited for double-stranded rDNA break resection

dsDNA breaks (DSBs) are resected in a 5′→3′ direction, generating single-stranded DNA (ssDNA). This promotes DNA repair by homologous recombination and also assembly of signaling complexes that activate the DNA damage checkpoint effector kinase Chk1. In fission yeast (Schizosaccharomyces pombe), gen...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Barnum, Kevin J., Nguyen, Y. Tram, O'Connell, Matthew J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514642/
https://ncbi.nlm.nih.gov/pubmed/30885940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005415
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