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XPG-related nucleases are hierarchically recruited for double-stranded rDNA break resection
dsDNA breaks (DSBs) are resected in a 5′→3′ direction, generating single-stranded DNA (ssDNA). This promotes DNA repair by homologous recombination and also assembly of signaling complexes that activate the DNA damage checkpoint effector kinase Chk1. In fission yeast (Schizosaccharomyces pombe), gen...
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| Pubblicato in: | J Biol Chem |
|---|---|
| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6514642/ https://ncbi.nlm.nih.gov/pubmed/30885940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005415 |
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