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Inhibition of Skp2 Sensitizes Chronic Myeloid Leukemia Cells to Imatinib

INTRODUCTION: Skp2 is an E3 ubiquitin ligase that plays an important role in modulating tumor progression. The mechanisms underlying Skp2 in the promotion of proliferation and its function in the primary resistance to tyrosine kinase inhibitors (TKIs) in human CML remain to be determined. This study...

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I publikationen:Cancer Manag Res
Huvudupphovsmän: Chen, Xiaowen, Huang, Zhenqi, Wu, Wei, Xia, Ruixiang
Materialtyp: Artigo
Språk:Inglês
Publicerad: Dove 2020
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7319929/
https://ncbi.nlm.nih.gov/pubmed/32606967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S253367
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