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Imatinib in Chronic Myeloid Leukemia: an Overview
Imatinib was the first signal transduction inhibitor (STI), used in a clinical setting. It prevents a BCR-ABL protein from exerting its role in the oncogenic pathway in chronic myeloid leukemia (CML). Imatinib directly inhibits the constitutive tyrosine kinase activity. Imatinib binds to BCR-ABL kin...
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| Formato: | Artigo |
| Lenguaje: | Inglês |
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Università Cattolica del Sacro Cuore
2014
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3894842/ https://ncbi.nlm.nih.gov/pubmed/24455116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4084/MJHID.2014.007 |
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