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Therapy of Chronic Myeloid Leukemia: Twilight of the Imatinib Era?
Chronic myeloid leukemia (CML) results from the clonal expansion of pluripotent hematopoietic stem cells containing the active BCR/ABL fusion gene produced by a reciprocal translocation of the ABL1 gene to the BCR gene. The BCR/ABL protein displays a constitutive tyrosine kinase activity and confers...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Publishing Corporation
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3929284/ https://ncbi.nlm.nih.gov/pubmed/24634785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/596483 |
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