KPT-330 inhibition of chromosome region maintenance 1 is cytotoxic and sensitizes chronic myeloid leukemia to Imatinib

As tyrosine kinase inhibitors (e.g., Imatinib, IM) fail to induce long-term response in some chronic myeloid leukemia (CML), novel therapies targeting leukemia-dysregulated pathways are necessary. Nuclear-cytoplasmic trafficking of proteins play a key role in the development of leukemia and drug res...

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Publicado no:Cell Death Discov
Main Authors: Nie, Danian, Huang, Kezhi, Yin, Songmei, Li, Yiqing, Xie, Shuangfeng, Ma, Liping, Wang, Xiuju, Wu, Yudan, Xiao, Jie, Wang, Jieyu, Yang, Wenjuan, Liu, Hongyun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913223/
https://ncbi.nlm.nih.gov/pubmed/29707241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-018-0049-2
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