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A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics

The transcription factors NF-κB and p53 are key regulators in the genotoxic stress response and are critical for tumor development. Although there is ample evidence for interactions between both networks, a comprehensive understanding of the crosstalk is lacking. Here, we developed a systematic appr...

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Publicat a:PLoS Comput Biol
Autors principals: Konrath, Fabian, Mittermeier, Anna, Cristiano, Elena, Wolf, Jana, Loewer, Alexander
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7319280/
https://ncbi.nlm.nih.gov/pubmed/32589666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007901
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