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Recent progress and open challenges in modeling p53 dynamics in single cells

In mammalian cells, the tumor suppressor p53 is activated upon a variety of cellular stresses and ensures an appropriate response ranging from arrest and repair to the induction of senescence and apoptosis. Quantitative measurements in individual living cells showed stimulus-dependent dynamics of p5...

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Detalhes bibliográficos
Publicado no:Curr Opin Syst Biol
Main Authors: Batchelor, Eric, Loewer, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650191/
https://ncbi.nlm.nih.gov/pubmed/29062976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coisb.2017.04.007
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