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A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics

The transcription factors NF-κB and p53 are key regulators in the genotoxic stress response and are critical for tumor development. Although there is ample evidence for interactions between both networks, a comprehensive understanding of the crosstalk is lacking. Here, we developed a systematic appr...

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Vydáno v:PLoS Comput Biol
Hlavní autoři: Konrath, Fabian, Mittermeier, Anna, Cristiano, Elena, Wolf, Jana, Loewer, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7319280/
https://ncbi.nlm.nih.gov/pubmed/32589666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007901
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