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Enzymatically inactive OGG1 binds to DNA and steers base excision repair toward gene transcription
8‐Oxoguanine DNA glycosylase1 (OGG1)‐initiated base excision repair (BER) is the primary pathway to remove the pre‐mutagenic 8‐oxo‐7,8‐dihydroguanine (8‐oxoG) from DNA. Recent studies documented 8‐oxoG serves as an epigenetic‐like mark and OGG1 modulates gene expression in oxidatively stressed cells...
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| Veröffentlicht in: | FASEB J |
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| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7318607/ https://ncbi.nlm.nih.gov/pubmed/32378256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902243R |
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