Enzymatically inactive OGG1 binds to DNA and steers base excision repair toward gene transcription

8‐Oxoguanine DNA glycosylase1 (OGG1)‐initiated base excision repair (BER) is the primary pathway to remove the pre‐mutagenic 8‐oxo‐7,8‐dihydroguanine (8‐oxoG) from DNA. Recent studies documented 8‐oxoG serves as an epigenetic‐like mark and OGG1 modulates gene expression in oxidatively stressed cells...

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Enregistré dans:
Détails bibliographiques
Publié dans:FASEB J
Auteurs principaux: Hao, Wenjing, Wang, Jing, Zhang, Yuanhang, Wang, Chenxin, Xia, Lan, Zhang, Wenhe, Zafar, Muhammad, Kang, Ju‐Yong, Wang, Ruoxi, Ali Bohio, Ameer, Pan, Lang, Zeng, Xianlu, Wei, Min, Boldogh, Istvan, Ba, Xueqing
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318607/
https://ncbi.nlm.nih.gov/pubmed/32378256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902243R
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