Enzymatically inactive OGG1 binds to DNA and steers base excision repair toward gene transcription

8‐Oxoguanine DNA glycosylase1 (OGG1)‐initiated base excision repair (BER) is the primary pathway to remove the pre‐mutagenic 8‐oxo‐7,8‐dihydroguanine (8‐oxoG) from DNA. Recent studies documented 8‐oxoG serves as an epigenetic‐like mark and OGG1 modulates gene expression in oxidatively stressed cells...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Hao, Wenjing, Wang, Jing, Zhang, Yuanhang, Wang, Chenxin, Xia, Lan, Zhang, Wenhe, Zafar, Muhammad, Kang, Ju‐Yong, Wang, Ruoxi, Ali Bohio, Ameer, Pan, Lang, Zeng, Xianlu, Wei, Min, Boldogh, Istvan, Ba, Xueqing
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318607/
https://ncbi.nlm.nih.gov/pubmed/32378256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902243R
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