Enzymatically inactive OGG1 binds to DNA and steers base excision repair toward gene transcription

8‐Oxoguanine DNA glycosylase1 (OGG1)‐initiated base excision repair (BER) is the primary pathway to remove the pre‐mutagenic 8‐oxo‐7,8‐dihydroguanine (8‐oxoG) from DNA. Recent studies documented 8‐oxoG serves as an epigenetic‐like mark and OGG1 modulates gene expression in oxidatively stressed cells...

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Bibliographic Details
Published in:FASEB J
Main Authors: Hao, Wenjing, Wang, Jing, Zhang, Yuanhang, Wang, Chenxin, Xia, Lan, Zhang, Wenhe, Zafar, Muhammad, Kang, Ju‐Yong, Wang, Ruoxi, Ali Bohio, Ameer, Pan, Lang, Zeng, Xianlu, Wei, Min, Boldogh, Istvan, Ba, Xueqing
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318607/
https://ncbi.nlm.nih.gov/pubmed/32378256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902243R
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