A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity

The limited efficacy of seasonal influenza vaccines is usually attributed to ongoing variation in the major antigenic targets for protective antibody responses including hemagglutinin (HA) and neuraminidase (NA). Hence, vaccine development has largely focused on broadening antigenic epitopes to gene...

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Udgivet i:Front Immunol
Main Authors: Sato-Kaneko, Fumi, Yao, Shiyin, Lao, Fitzgerald S., Shpigelman, Jonathan, Messer, Karen, Pu, Minya, Shukla, Nikunj M., Cottam, Howard B., Chan, Michael, Chu, Paul J., Burkhart, David, Schoener, Roman, Matsutani, Takaji, Carson, Dennis A., Corr, Maripat, Hayashi, Tomoko
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318308/
https://ncbi.nlm.nih.gov/pubmed/32636840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01207
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