Identification of Compounds that Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants

Vaccines are reliant on adjuvants to enhance the immune stimulus and type I interferons (IFNs) have been shown to be beneficial in augmenting this response. We were interested to identify compounds that would sustain activation of an endogenous type I IFN response as a co-adjuvant. We began with gen...

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Detalhes bibliográficos
Publicado no:SLAS Discov
Main Authors: Shukla, Nikunj M., Arimoto, Kei-Ichiro, Yao, Shiyin, Fan, Jun-Bao, Zhang, Yue, Sato-Kaneko, Fumi, Lao, Fitzgerald S., Hosoya, Tadashi, Messer, Karen, Pu, Minya, Cottam, Howard B., Carson, Dennis A., Hayashi, Tomoko, Zhang, Dong-Er, Corr, Maripat
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697428/
https://ncbi.nlm.nih.gov/pubmed/29751735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555218774308
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