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Mechanisms of γ-Secretase Activation and Substrate Processing
[Image: see text] Amyloid β-peptide, the principal component of characteristic cerebral plaques of Alzheimer’s disease (AD), is produced through intramembrane proteolysis of the amyloid precursor protein (APP) by γ-secretase. Despite the importance in the pathogenesis of AD, the mechanisms of intram...
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| Veröffentlicht in: | ACS Cent Sci |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical Society
2020
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7318072/ https://ncbi.nlm.nih.gov/pubmed/32607444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c00296 |
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