Structural Basis of Reduced Susceptibility to Ceftazidime-Avibactam and Cefiderocol in Enterobacter cloacae Due to AmpC R2 Loop Deletion

Ceftazidime-avibactam and cefiderocol are two of the latest generation β-lactam agents that possess expanded activity against highly drug-resistant bacteria, including carbapenem-resistant Enterobacterales. Here, we show that structural changes in AmpC β-lactamases can confer reduced susceptibility...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Kawai, Akito, McElheny, Christi L., Iovleva, Alina, Kline, Ellen G., Sluis-Cremer, Nicolas, Shields, Ryan K., Doi, Yohei
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318025/
https://ncbi.nlm.nih.gov/pubmed/32284381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00198-20
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