Characterization of KPC-82, a KPC-2 Variant Conferring Resistance to Ceftazidime-Avibactam in a Carbapenem-Nonsusceptible Clinical Isolate of Citrobacter koseri

KPC-82 is a KPC-2 variant identified in a carbapenem-nonsusceptible Citrobacter koseri that confers high-level resistance to ceftazidime-avibactam. Genomic analysis revealed that bla(KPC-82) is carried by a chromosomally integrated Tn4401 transposon (disrupting porin gene phoE) and evolved by a 6-nu...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Lebreton, Francois, Corey, Brendan W., McElheny, Christi L., Iovleva, Alina, Preston, Lan, Margulieux, Katie R., Cybulski, Robert J., Mc Gann, Patrick, Doi, Yohei, Bennett, Jason W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2021
Aiheet:
Mechanisms of Resistance
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218621/
https://ncbi.nlm.nih.gov/pubmed/33972237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00150-21
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