Population Pharmacokinetics of Piperacillin following Continuous Infusion in Critically Ill Patients and Impact of Renal Function on Target Attainment

Pharmacokinetic changes are often seen in patients with severe infections. Administration by continuous infusion has been suggested to optimize antibiotic exposure and pharmacokinetic/pharmacodynamic (PK/PD) target attainment for β-lactams. In an observational study, unbound piperacillin concentrati...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Klastrup, Vibeke, Thorsted, Anders, Storgaard, Merete, Christensen, Steffen, Friberg, Lena E., Öbrink-Hansen, Kristina
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Clinical Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318020/
https://ncbi.nlm.nih.gov/pubmed/32284376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02556-19
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