Population Pharmacokinetics of Piperacillin in Sepsis Patients: Should Alternative Dosing Strategies Be Considered?

Sufficient antibiotic dosing in septic patients is essential for reducing mortality. Piperacillin-tazobactam is often used for empirical treatment, but due to the pharmacokinetic (PK) variability seen in septic patients, optimal dosing may be a challenge. We determined the PK profile for piperacilli...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Andersen, Maria Goul, Thorsted, Anders, Storgaard, Merete, Kristoffersson, Anders N., Friberg, Lena E., Öbrink-Hansen, Kristina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923116/
https://ncbi.nlm.nih.gov/pubmed/29507062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02306-17
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