Population Pharmacokinetics of Piperacillin following Continuous Infusion in Critically Ill Patients and Impact of Renal Function on Target Attainment

Pharmacokinetic changes are often seen in patients with severe infections. Administration by continuous infusion has been suggested to optimize antibiotic exposure and pharmacokinetic/pharmacodynamic (PK/PD) target attainment for β-lactams. In an observational study, unbound piperacillin concentrati...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Klastrup, Vibeke, Thorsted, Anders, Storgaard, Merete, Christensen, Steffen, Friberg, Lena E., Öbrink-Hansen, Kristina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318020/
https://ncbi.nlm.nih.gov/pubmed/32284376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02556-19
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