In Vitro Pharmacological Profile of a New Small Molecule Bradykinin B(2) Receptor Antagonist

We here report the discovery and early characterization of Compound 3, a representative of a novel class of small molecule bradykinin (BK) B(2) receptor antagonists, and its superior profile to the prior art B(2) receptor antagonists Compound 1 and Compound 2. Compound 3, Compound 2, and Compound 1...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Lesage, Anne, Gibson, Christoph, Marceau, François, Ambrosi, Horst-Dieter, Saupe, Jörn, Katzer, Werner, Loenders, Brigitte, Charest-Morin, Xavier, Knolle, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316994/
https://ncbi.nlm.nih.gov/pubmed/32636746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00916
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