Pharmacological evidence of bradykinin regeneration from extended sequences that behave as peptidase–activated B(2) receptor agonists

While bradykinin (BK) is known to be degraded by angiotensin converting enzyme (ACE), we have recently discovered that Met-Lys-BK-Ser-Ser is paradoxically activated by ACE. We designed and evaluated additional “prodrug” peptides extended around the BK sequence as potential ligands that could be loca...

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Detalhes bibliográficos
Main Authors: Charest-Morin, Xavier, Roy, Caroline, Fortin, Émile-Jacques, Bouthillier, Johanne, Marceau, François
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945637/
https://ncbi.nlm.nih.gov/pubmed/24639651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00032
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