Pharmacological evidence of bradykinin regeneration from extended sequences that behave as peptidase–activated B(2) receptor agonists

While bradykinin (BK) is known to be degraded by angiotensin converting enzyme (ACE), we have recently discovered that Met-Lys-BK-Ser-Ser is paradoxically activated by ACE. We designed and evaluated additional “prodrug” peptides extended around the BK sequence as potential ligands that could be loca...

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Detaylı Bibliyografya
Asıl Yazarlar: Charest-Morin, Xavier, Roy, Caroline, Fortin, Émile-Jacques, Bouthillier, Johanne, Marceau, François
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2014
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945637/
https://ncbi.nlm.nih.gov/pubmed/24639651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00032
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