Species-specific pharmacology of maximakinin, an amphibian homologue of bradykinin: putative prodrug activity at the human B2 receptor and peptidase resistance in rats

Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B2 receptor (B2R) agonist eliciting prolonged signaling. We reinvestigated this 19-mer for species-specific pharmacologic profile, in vivo confirmation of resistance to inactivation by angiotensin c...

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Hlavní autoři: Xavier Charest-Morin, Hélène Bachelard, Melissa Jean, Francois Marceau
Médium: Artigo
Jazyk:Inglês
Vydáno: PeerJ Inc. 2017-01-01
Edice:PeerJ
Témata:
Bradykinin B2 receptor
Maximakinin
MRGPRX2
Human umbilical vein
Angiotensin converting enzyme
In vivo hemodynamics
On-line přístup:https://peerj.com/articles/2911.pdf
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