Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cell-derived cardiomyocytes

Doxorubicin is a potent anticancer drug used to treat a variety of cancer types. However, its use is limited by doxorubicin-induced cardiotoxicity (DIC). A missense variant in the RARG gene (S427L; rs2229774) has been implicated in susceptibility to DIC in a genome wide association study. The goal o...

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Udgivet i:Sci Rep
Main Authors: Christidi, Effimia, Huang, Haojun, Shafaattalab, Sanam, Maillet, Agnes, Lin, Eric, Huang, Kate, Laksman, Zachary, Davis, Margot K., Tibbits, Glen F., Brunham, Liam R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316788/
https://ncbi.nlm.nih.gov/pubmed/32587261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65979-x
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