Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes

Doxorubicin is a highly efficacious anti-cancer drug but causes cardiotoxicity in many patients. The mechanisms of doxorubicin-induced cardiotoxicity (DIC) remain incompletely understood. We investigated the characteristics and molecular mechanisms of DIC in human pluripotent stem cell-derived cardi...

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Udgivet i:Sci Rep
Main Authors: Maillet, Agnes, Tan, Kim, Chai, Xiaoran, Sadananda, Singh N., Mehta, Ashish, Ooi, Jolene, Hayden, Michael R., Pouladi, Mahmoud A., Ghosh, Sujoy, Shim, Winston, Brunham, Liam R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855185/
https://ncbi.nlm.nih.gov/pubmed/27142468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25333
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