Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

Disruption of mitochondrial function selectively targets tumour cells that are dependent on oxidative phosphorylation. However, due to their high energy demands, cardiac cells are disproportionately targeted by mitochondrial toxins resulting in a loss of cardiac function. An analysis of the effects...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Stephenson, Zoe A, Harvey, Robert F, Pryde, Kenneth R, Mistry, Sarah, Hardy, Rachel E, Serreli, Riccardo, Chung, Injae, Allen, Timothy EH, Stoneley, Mark, MacFarlane, Marion, Fischer, Peter M, Hirst, Judy, Kellam, Barrie, Willis, Anne E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316505/
https://ncbi.nlm.nih.gov/pubmed/32432547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55845
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