Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

Disruption of mitochondrial function selectively targets tumour cells that are dependent on oxidative phosphorylation. However, due to their high energy demands, cardiac cells are disproportionately targeted by mitochondrial toxins resulting in a loss of cardiac function. An analysis of the effects...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Stephenson, Zoe A, Harvey, Robert F, Pryde, Kenneth R, Mistry, Sarah, Hardy, Rachel E, Serreli, Riccardo, Chung, Injae, Allen, Timothy EH, Stoneley, Mark, MacFarlane, Marion, Fischer, Peter M, Hirst, Judy, Kellam, Barrie, Willis, Anne E
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2020
Teme:
Biochemistry and Chemical Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316505/
https://ncbi.nlm.nih.gov/pubmed/32432547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55845
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