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DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
DNA topoisomerases are the targets of important anticancer and antibacterial drugs. Camptothecins and novel noncamptothecins in clinical development (indenoisoquinolines and ARC-111) target eukaryotic type IB topoisomerases (Top1), whereas human type IIA topoisomerases (Top2α and Top2β) are the targ...
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| Published in: | Chem Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7316379/ https://ncbi.nlm.nih.gov/pubmed/20534341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.04.012 |
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