Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II

BACKGROUND: Topoisomerase II is critical for DNA replication, transcription and chromosome segregation and is a well validated target of anti-neoplastic drugs including the anthracyclines and epipodophyllotoxins. However, these drugs are limited by common tumor resistance mechanisms and side-effect...

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Autori principali: Hawtin, Rachael E., Stockett, David E., Byl, Jo Ann W., McDowell, Robert S., Tan, Nguyen, Arkin, Michelle R., Conroy, Andrew, Yang, Wenjin, Osheroff, Neil, Fox, Judith A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855444/
https://ncbi.nlm.nih.gov/pubmed/20419121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010186
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