EPCR deficiency or function-blocking antibody protects against joint bleeding–induced pathology in hemophilia mice

We recently showed that clotting factor VIIa (FVIIa) binding to endothelial cell protein C receptor (EPCR) induces anti-inflammatory signaling and protects vascular barrier integrity. Inflammation and vascular permeability are thought to be major contributors to the development of hemophilic arthrop...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood
Egile Nagusiak: Magisetty, Jhansi, Pendurthi, Usha R., Esmon, Charles T., Rao, L. Vijaya Mohan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2020
Gaiak:
Plenary Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316205/
https://ncbi.nlm.nih.gov/pubmed/32294155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003824
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