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EPCR deficiency or function-blocking antibody protects against joint bleeding–induced pathology in hemophilia mice
We recently showed that clotting factor VIIa (FVIIa) binding to endothelial cell protein C receptor (EPCR) induces anti-inflammatory signaling and protects vascular barrier integrity. Inflammation and vascular permeability are thought to be major contributors to the development of hemophilic arthrop...
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| Pubblicato in: | Blood |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7316205/ https://ncbi.nlm.nih.gov/pubmed/32294155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003824 |
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