Physiologically Based Pharmacokinetic Models to Predict Maternal Pharmacokinetics and Fetal Exposure to Emtricitabine and Acyclovir

Pregnancy is associated with physiological changes that may impact drug pharmacokinetics (PK). The goals of this study were to build maternal-fetal physiologically based pharmacokinetic (PBPK) models for acyclovir and emtricitabine, 2 anti(retro)viral drugs with active renal net secretion, and to (1...

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Detalhes bibliográficos
Publicado no:J Clin Pharmacol
Main Authors: Liu, Xiaomei I., Momper, Jeremiah D., Rakhmanina, Natella, van den Anker, John N., Green, Dionna J., Burckart, Gilbert J., Best, Brookie M., Mirochnick, Mark, Capparelli, Edmund V., Dallmann, André
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316130/
https://ncbi.nlm.nih.gov/pubmed/31489678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1515
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