Physiologically Based Pharmacokinetic Models to Predict Maternal Pharmacokinetics and Fetal Exposure to Emtricitabine and Acyclovir

Pregnancy is associated with physiological changes that may impact drug pharmacokinetics (PK). The goals of this study were to build maternal-fetal physiologically based pharmacokinetic (PBPK) models for acyclovir and emtricitabine, 2 anti(retro)viral drugs with active renal net secretion, and to (1...

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Bibliografiska uppgifter
I publikationen:J Clin Pharmacol
Huvudupphovsmän: Liu, Xiaomei I., Momper, Jeremiah D., Rakhmanina, Natella, van den Anker, John N., Green, Dionna J., Burckart, Gilbert J., Best, Brookie M., Mirochnick, Mark, Capparelli, Edmund V., Dallmann, André
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316130/
https://ncbi.nlm.nih.gov/pubmed/31489678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1515
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