Prediction of maternal and fetal pharmacokinetics of dolutegravir and raltegravir using physiologically-based pharmacokinetic modeling

BACKGROUND: Predicting drug pharmacokinetics (PK) in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal-fetal physiologically-based PK (PBPK) models for two antiretroviral drugs (ARVs), dolutegravir (DTG) and raltegravir (RAL). MET...

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Detaylı Bibliyografya
Yayımlandı:Clin Pharmacokinet
Asıl Yazarlar: Liu, Xiaomei I., Momper, Jeremiah D., Rakhmanina, Natella Y., Green, Dionna J., Burckart, Gilbert J., Cressey, Tim R., Mirochnick, Mark, Best, Brookie M., van den Anker, John N., Dallmann, André
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666002/
https://ncbi.nlm.nih.gov/pubmed/32451908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-020-00897-9
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