Prediction of maternal and fetal pharmacokinetics of dolutegravir and raltegravir using physiologically-based pharmacokinetic modeling

BACKGROUND: Predicting drug pharmacokinetics (PK) in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal-fetal physiologically-based PK (PBPK) models for two antiretroviral drugs (ARVs), dolutegravir (DTG) and raltegravir (RAL). MET...

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Publicat a:Clin Pharmacokinet
Autors principals: Liu, Xiaomei I., Momper, Jeremiah D., Rakhmanina, Natella Y., Green, Dionna J., Burckart, Gilbert J., Cressey, Tim R., Mirochnick, Mark, Best, Brookie M., van den Anker, John N., Dallmann, André
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7666002/
https://ncbi.nlm.nih.gov/pubmed/32451908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-020-00897-9
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