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Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease
[Image: see text] Sickle cell disease (SCD) is caused by a single nucleotide polymorphism on chromosome 11 in the β-globin gene. The resulting mutant hemoglobin S (HbS) is a poor oxygen transporter and causes a variety of vascular symptoms and organ failures. At birth, the DRED epigenetic complex fo...
Shranjeno v:
| izdano v: | ACS Omega |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical Society
2020
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7315572/ https://ncbi.nlm.nih.gov/pubmed/32596612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c01585 |
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