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Dual inhibitors of LSD1 and spermine oxidase
We have previously described the synthesis and evaluation of 3,5-diamino-1,2,4-triazole analogues as inhibitors of the flavin-dependent histone demethylase LSD1. These compounds are potent inhibitors of LSD1 without activity against monoamine oxidases A and B, and promote the elevation of H3K4me2 le...
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| Pubblicato in: | Medchemcomm |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6533887/ https://ncbi.nlm.nih.gov/pubmed/31191868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00610e |
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