Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia

Ph(+) acute lymphoblastic leukemia (ALL) is characterized by the expression of an oncogenic fusion kinase termed BCR-ABL1. Here, we show that interleukin 7 receptor (IL7R) interacts with the chemokine receptor CXCR4 to recruit BCR-ABL1 and JAK kinases in close proximity. Treatment with BCR-ABL1 kina...

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Published in:Nat Commun
Main Authors: Abdelrasoul, Hend, Vadakumchery, Anila, Werner, Markus, Lenk, Lennart, Khadour, Ahmad, Young, Marc, El Ayoubi, Omar, Vogiatzi, Fotini, Krämer, Markus, Schmid, Vera, Chen, Zhengshan, Yousafzai, Yasar, Cario, Gunnar, Schrappe, Martin, Müschen, Markus, Halsey, Christina, Mulaw, Medhanie A., Schewe, Denis M., Hobeika, Elias, Alsadeq, Ameera, Jumaa, Hassan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314847/
https://ncbi.nlm.nih.gov/pubmed/32581241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16927-w
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