A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells

Translesion DNA synthesis (TLS) performed by human DNA polymerase eta (hpol η) allows tolerance of damage from cis-diamminedichloroplatinum(II) (CDDP or cisplatin). We have developed hpol η inhibitors derived from N-aryl-substituted indole barbituric acid (IBA), indole thiobarbituric acid (ITBA), an...

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Détails bibliographiques
Publié dans:Biochemistry
Auteurs principaux: Zafar, Maroof K., Maddukuri, Leena, Ketkar, Amit, Penthala, Narsimha R., Reed, Megan R., Eddy, Sarah, Crooks, Peter A., Eoff, Robert L.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312786/
https://ncbi.nlm.nih.gov/pubmed/29345908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b01176
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