Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

In humans, disruption of nonsense-mediated decay (NMD) has been associated with neurodevelopmental disorders (NDDs) such as autism spectrum disorder and intellectual disability. However, the mechanism by which deficient NMD leads to neurodevelopmental dysfunction remains unknown, preventing developm...

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Vydáno v:Neuron
Hlavní autoři: Johnson, Jennifer L., Stoica, Loredana, Liu, Yuwei, Zhu, Ping Jun, Bhattacharya, Abhisek, Buffington, Shelly A., Huq, Redwan, Eissa, N. Tony, Larsson, Ola, Porse, Bo T., Domingo, Deepti, Nawaz, Urwah, Carroll, Renee, Jolly, Lachlan, Scerri, Tom S., Kim, Hyung-Goo, Brignell, Amanda, Coleman, Matthew J., Braden, Ruth, Kini, Usha, Jackson, Victoria, Baxter, Anne, Bahlo, Melanie, Scheffer, Ingrid E., Amor, David J., Hildebrand, Michael S., Bonnen, Penelope E., Beeton, Christine, Gecz, Jozef, Morgan, Angela T., Costa-Mattioli, Mauro
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312756/
https://ncbi.nlm.nih.gov/pubmed/31585809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.08.027
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