CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape

Chimeric antigen receptor (CAR) T cell therapies have demonstrated remarkable efficacy for the treatment of hematological malignancies. However, in patients with solid tumors, objective responses to CAR-T cell therapy remain sporadic and transient. A major obstacle for CAR-T cells is the intrinsic a...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Rodriguez-Garcia, Alba, Palazon, Asis, Noguera-Ortega, Estela, Powell, Daniel J., Guedan, Sonia
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311654/
https://ncbi.nlm.nih.gov/pubmed/32625204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01109
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